Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 22nd World Congress on Advances in Nanoscience and Nanotechnology Singapore.

Day :

  • Nanomedicine

Session Introduction

Ahmed Raza Khan

Australian National University, Australia

Title: Tunable optoelectronic properties of ws2 by local Strain engineering and folding
Biography:

Ahmed Raza Khan is assiliated from Australian National University, Australia

Abstract:

Local-strain engineering is an exciting approach to tune the optoelectronic properties of materials and enhance the performance of devices. Two dimensional (2D) materials such as 2D transition metal dichalcogenides (TMDCs) are particularly well-suited for this purpose because they have high flexibility and can withstand high deformations before rupture. Wrinkles on thick TMDC layers have been reported to show the interesting photoluminescence enhancement due to bandgap modulation and funneling effect. However, the wrinkles in ultrathin TMDCs have not been investigated, because the wrinkles can easily fall down to form folds in these ultrathin layers of TMDCs. Here, we have achieved both wrinkle and fold nano-structures simultaneously on 1-3L WS2 using a new fabrication technique. The comparable layer dependent reduction in surface potential is observed for both folded layers and corresponding perfect pack layers due to the dominant interlayer screening effect. The strains produced from the wrinkle nanostructures considerably vary semi conductive junction properties. Thermo-ionic modelling suggests that the strained (1.6%) wrinkles can lower the Schottky barrier height (SBH) by 20%. The photo-generated carriers would further significantly lower the SBH. These results present an important advance towards controlling the optoelectronic properties of atomically thin WS2 using strain engineering, with important implications for practical device applications.

Biography:

Ratih Dyah Pertiwi has completed his master  from Universitas Indonesia and he was studying doctoral studies from Universitas Gajah Mada, faculty of Pharmacy. He is a lecturer of department Pharmacy, Universitas Esa Unggul, Jakarta, Indonesia.

Abstract:

The methods like biogreen are advantageous over chemical and physical methods due to eco friendly and cost-effective synthesis of nanoparticles. Current study was designed for green synthesis of gold nanoparticles (GNPs) and their biological evaluation. Aqua extract of Muntingia calabura, Linn was used for the synthesis of GNPs and confirmed by UV visible and Fourier Transform Infra-Red (FTIR) spectroscopy. Further field emission Transmision electron microscope (TEM)  and Particle Size Analyser was used for the shape zeta potential and size determination.  In vitro Antioxidant, and tyrosinase inhibitor was determined by using standard protocols. The nanoparticles were spherical in shape and having average particle size of 88 nm. FTIR analysis revealed the possible involvement of phyto-constituents in gold nanoparticles of crude extract. Green synthesized nanoparticles showed the enhanced antioxidant properties and the tyrosinase inhibitor. Green synthesized GNPs showed enhanced biological activities. Present results also support the advantages of using biogreen method for the production of nanoparticles having the potential of antimicrobial and cytotoxic activities.

Biography:

Anh Le Mong is going to study in Ms-PhD combined program at Sungkyunkwan University with corresponding by Professsor Dukjoon Kim, SKKU Fellow Professor at School of Chemical Engineering in Sungkyunkwan University National Academy of Engineering of Korea, Suwon, Gyeonggi 16419, Republic of Korea.

Abstract:

A series of alkaline anion exchange membranes (AAEMs) are synthesized from poly(arylene ether ketone)-poly(vinyl-1-butylimidazolium) graft copolymers (PAEK-g-[PBVIm-OH]) with different [PBVIm-OH] cationic chain lengths. The chemical structure of the synthesized polymers is confirmed by proton nuclear magnetic resonance (1H-NMR) and Fourier-transform infrared spectroscopy (FTIR) analysis. Several essential properties of AAEMs such as water uptake, hydroxide ion conductivity, and thermal, mechanical and dimensional stability for fuel cell applications are investigated and correlated to the ion cluster dimension examined by small-angle X-ray scattering (SAXS). The PAEK-g-[PBVIm-OH]-based AAEMs show excellent hydroxide ion conductivity as well as thermal, mechanical, and dimensional stability. The hydroxide ion conductivity increases with increasing PBVIm-OH graft chain length. The AAEM membrane with the longest PBVIm-OH chain length (MW of ~ 7000 g mol-1) exhibits the highest hydroxide conductivity of 0.00878 S cm-1 at 40 oC and the highest elongation of 206.7% in the hydrate state. The membrane electrode assembly fabricated from this membrane shows the highest power density of 22 mW cm-2 at a current density of 55 mA cm-2, which is very promising for fuel cell applications

Biography:

Ting-Yu Lee has his expertise in vascular biology, hemodynamics-modulated endothelial dysfunction, epigenetic factors, histone deactylase, and miRNAs. He uses in vitro flow system to identify the role of miR-10a in hemodynamics-modulated EC function, and develop miR-10a as hemodynamics-based therapeutic components for atherosclerosis treatment

Abstract:

Statement of the Problem: Hemodynamic forces, i.e. pro-atherogenic oscillatory flow (OS) and atheroprotective pulsatile flow (PS), have been identified to be the vital factors to modulate endothelial cell (EC) dysfunction and function. However, the relationship between hormone receptor and microRNA (miRs) in hemodynamics-modulated EC function remain unclear. Methodology & Theoretical Orientation: The aim of this study is to elucidate the role of RARa-directed miR-10a signaling in hemodynamics-modulating EC function and dysfunction. In vitro flow system was used to generate OS and PS to investigate the effect of hemodynamic forces on miR-10a signaling and EC dysfunction, and its underlying mechanism. In vivo apolipoprotein E-deficient (ApoE-/-) mice model was used to evaluate the therapeutic effect of miR-10a on atherosclerosis. Conclusion & Significance: Our results showed that miR-10a is the miR with the lowest expression among all examined shear-responsive miRs in ECs in response to pro-atherogenic OS, and has relatively higher expression than other shear-responsive miRs in ECs in response to atheroprotective PS. MiR-10a targets transcriptional factor GATA6 to modulate pro-inflammatory VCAM-1, which is differentially regulated by atherogenic OS and atheroprotective PS. Mechanistically, hormone receptor RARα (director) and RXRα (enhancer) are induced by atheroprotective PS to form heterodimer in the nucleus to enhance miR-10a expression to inhibit pro-inflammatory GATA6/VCAM-1 signaling. In contrast, HDAC-3/-5/-7 (repressors) are induced by atherogenic OS to associate with RARα to repress RARα-directed miR-10a signaling. Finally, our data on ApoE-/- mice model demonstrated that systemic delivery of miR-10a induces the expression of endothelial miR-10a to repress GATA6/VCAM-1 signaling, and subsequently inhibits the formation of atherosclerosis. Our findings provide new insight that RXRα and HDAC-3/5/7 constitute a regulatory machinery to switch the role of hormone receptor RARα in modulating miR-10a/GATA6/VCAM-1 signaling in ECs in response to different flow patterns. Moreover, in vivo induction of endothelial miR-10a inhibits the 
progression of atherosclerosis.